List of selected Publications

Park JY, Sunga O, Wanitphakdeedecha R, Frevert J. Neurotoxin Impurities: A Review of Threats to Efficacy. Plast Reconstr Surg Glob Open. 2020 Jan 24;8(1):e2627.

Kerscher M, Wanitphakdeedecha R, Trindade de Almeida A, Maas C, Frevert J. IncobotulinumtoxinA: A Highly Purified and Precisely Manufactured Botulinum Neurotoxin Type A. J Drugs Dermatol. 2019 Jan 1;18(1):52-57

Frevert J, Ahn KY, Park MY, Sunga O. Comparison of botulinum neurotoxin type A formulations in Asia. Clin Cosmet Investig Dermatol. 2018 Jul 5;11:327-331

López de la Paz M, Scheps D, Jurk M, Hofmann F, Frevert J. Rational design of botulinum neurotoxin A1 mutants with improved oxidative stability. Toxicon. 2018 Jun 1;147:54-57

Frevert J. Pharmaceutical, biological, and clinical properties of botulinum neurotoxin type A products. Drugs R D. 2015 Mar;15(1):1-9

Frevert J. Content of botulinum neurotoxin in Botox®/Vistabel®, Dysport®/Azzalure®, and Xeomin®/Bocouture®. Drugs R D. 2010;10(2):67-73

Bigalke H, Frevert J. Botulinum toxin A: dose and immune response. Int J Rehabil Res. 2012 Jun;35(2):93

Frevert J, Dressler D. Complexing proteins in botulinum toxin type A drugs: a help or a hindrance? Biologics. 2010 Dec 9;4:325-32

Frevert J. Xeomin is free from complexing proteins. Toxicon. 2009 Oct;54(5):697-701

Heinemann U, Frevert J, Hofmann K, Illing G, Maurer C, Oschkinat H, Saenger W. An integrated approach to structural genomics. Prog Biophys Mol Biol. 2000;73(5):347-62

Salas JA, Rohr J. The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin. Angew Chem Int Ed Engl. 2000 Feb;39(4):796-799

Abreu PM, Martins ES, Kayser O, Bindseil KU, Siems K, Seemann A, Frevert J. Antimicrobial, antitumor and antileishmania screening of medicinal plants from Guinea-Bissau. Phytomedicine. 1999 Jul;6(3):187-95

Göschel H, Wohlfarth K, Frevert J, Dengler R, Bigalke H. Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies–therapeutic consequences. Exp Neurol. 1997 Sep;147(1):96-102

Wohlfarth K, Göschel H, Frevert J, Dengler R, Bigalke H. Botulinum A toxins: units versus units. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):335-40

Erdal E, Bartels F, Binscheck T, Erdmann G, Frevert J, Kistner A, Weller U, Wever J, Bigalke H. Processing of tetanus and botulinum A neurotoxins in isolated chromaffin cells. Naunyn Schmiedebergs Arch Pharmacol. 1995 Jan;351(1):67-78

Bartels F, Bergel H, Bigalke H, Frevert J, Halpern J, Middlebrook J. Specific antibodies against the Zn(2+)-binding domain of clostridial neurotoxins restore exocytosis in chromaffin cells treated with tetanus or botulinum A neurotoxin. J Biol Chem. 1994 Mar 18;269(11):8122-7

Maier K, Ehrhardt G, Frevert J. Antibacterial activity of cultured human keratinocytes. Arch Dermatol Res. 1992;284(2):119-21

Spranz E, Siegemund B, Frevert J, Knoell HE. Study on the penetration of tetanus toxoid through the nasal mucosa. Arch Toxicol Suppl. 1991;14:276-9

Binz T, Kurazono H, Wille M, Frevert J, Wernars K, Niemann H. The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins. J Biol Chem. 1990 Jun
5;265(16):9153-8 mucosa. Arch Toxicol Suppl. 1991;14:276-9

Bette P, Frevert J, Mauler F, Suttorp N, Habermann E. Pharmacological and biochemical studies of cytotoxicity of Clostridium novyi type A alpha-toxin. Infect Immun. 1989 Aug;57(8):2507-13

Aktories K, Frevert J. ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotide. Biochem J. 1987 Oct 15;247(2):363-8

Frevert J, Ballou CE. Saccharomyces cerevisiae structural cell wall mannoprotein. Biochemistry. 1985 Jan 29;24(3):753-9

Tsai PK, Frevert J, Ballou CE. Carbohydrate structure of Saccharomyces cerevisiae mnn9 mannoprotein. J Biol Chem. 1984 Mar 25;259(6):3805-11

Frevert J, Ballou CE. Yeast invertase polymorphism is correlated with variable states of oligosaccharide chain phosphorylation. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6147-50

Frevert J, Köller W, Kindl H. Occurrence and biosynthesis of glyoxysomal enzymes in ripening cucumber seeds. Hoppe Seylers Z Physiol Chem. 1980 Oct;361(10):1557-65

Frevert J, Kindl H. Purification of glyoxysomal acetyl-CoA acyltransferase. Hoppe Seylers Z Physiol Chem. 1980 Apr;361(4):537-42

Frevert J, Kindl H. A bifunctional enzyme from glyoxysomes. Purification of a protein possessing enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities. Eur J Biochem.
1980;107(1):79-86

Kindl H, Köller W, Frevert J. Cytosolic precursor pools during glyoxysome biosynthesis. Hoppe Seylers Z Physiol Chem. 1980;361(3):465-7

Köller W, Frevert J, Kindl H. Albumins, glyoxysomal enzymes and globulins in dry seeds of cucumis sativus: qualitative and quantitative analysis. Hoppe Seylers Z Physiol Chem. 1979 Feb;360(2):167-76

Frevert J, Kindl H. Plant microbody proteins. Purification and glycoprotein nature of glyoxysomal isocitrate lyase from cucumber cotyledons. Eur J Biochem. 1978 Dec 1;92(1):35-43